Secretory phospholipase A2 type IIA: a regulator of immune function in atherosclerosis?

Secretory phospholipase A2 type IIA: a regulator of immune function in atherosclerosis?

Soluble phospholipase A2 type IIA (sPLA2-IIA) is an acutephase reactant that is markedly increased in inflammatory disorders including cardiovascular disease. Inflammatory cytokines such as interleukins IL-6 and IL-1b, interferon (IFN)-g, and tumour necrosis factor (TNF)-a increase its expression in vascular smooth muscle cells and hepatocytes, two cell types largely responsible for its elevati...

Type IIA Secretory Phospholipase A

effect of polyunsaturated fatty acids on secretory phospholipase a2 type iia in ectopic endometrial cells

background: endometriosis is a common chronic inflammation which leads to infertility and chronic pelvic pain in affected women. secretory phospholipase a2 type iia (spla2iia) is an acute phase reactant that is markedly increased in inflammatory disorders. objective: to assess the effects of ω-3 and ω-6 polyunsaturated fatty acids (pufas) administration in endometrial cells culture on spla2iia ...

Secretory Phospholipase A2, Type IIA, A Biomarker of Septic Arthritis In Children With Joint Irritability

Cite this article: Ugalde IT, Hennes H, Copley L, Huang R, Baker MD (2014) Secretory Phospholipase A2, Type IIA, A Biomarker of Septic Arthritis In Children With Joint Irritability. Ann Orthop Rheumatol 2(3): 1021. *Corresponding author Ugalde, Pediatrics Section of Emergency Medicine, Department of Pediatrics, Baylor College of Medicine, 6621 Fannin St. A.2210, Houston, TX 77030, Tel: 832-8246...

Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury.

The aim of this study was to evaluate the presence of type-II secretory phospholipase A2 (sPLA2-IIA) in alveolar space and its possible role in the destruction of surfactant in three rat models of acute lung injury. Alveolar instillation of either lipopolysaccaride or live Pseudomonas aeruginosa resulted in a significant increase in lung oedema and in a decrease in static compliance of the resp...